Functionally Differentiated Cell Lines

cells by cytotoxic T cells, restricted by HLA antigens, is discussed in the context of T cell antigen recognition. Finally, the statistical associations between HLA-Dr antigens and diseases are presented in a well-referenced table, along with the method of statistical analysis. However, those interested in possible mechanisms or immune significance of these associations will have to look elsewhere. Of better known etiology, are the immunodeficency diseases caused by inherited defects of purine metabolism, the topic of another article. Disease has unfortunately long been the key to understanding many normal human physiological functions. This book approaches immunoregulation through a discussion of its aberrant extremes, immunodeficency and autoimmunity. T cell neoplasms which maintain regulatory functions are important in this regard, too. Also related is an article discussing the production of long-term cultures of immunocompetent T lymphocytes, an important tool in the dissection of immune regulation and lymphocyte biology. This volume encompasses a broad range of topics only some of which are detailed above. It is not, nor does it try to be, a comprehensive overview of T lymphocytes. As noted, it is limited, with a few exceptions, to human immunobiology. It contains some articles of purely clinical interest although the majority possess wider appeal. The articles are generally brief but well written, holding greatest interest for those with some immunological background. The book is recommended for those in medicine and those in research who are less familiar with human systems.